Final standings · 2021
| # | Team | P | W | D | L | Diff | Pts |
|---|---|---|---|---|---|---|---|
| 1 | New England Revolution | 34 | 22 | 7 | 5 | +24 | 73 |
| 2 | Philadelphia Union | 34 | 14 | 12 | 8 | +13 | 54 |
| 3 | Nashville SC | 34 | 12 | 18 | 4 | +22 | 54 |
| 4 | New York City FC | 34 | 14 | 9 | 11 | +20 | 51 |
| 5 | Atlanta United FC | 34 | 13 | 12 | 9 | +8 | 51 |
| 6 | Orlando City SC | 34 | 13 | 12 | 9 | +2 | 51 |
| 7 | New York Red Bulls | 34 | 13 | 9 | 12 | +6 | 48 |
| 8 | DC United | 34 | 14 | 5 | 15 | +2 | 47 |
| 9 | Columbus Crew | 34 | 13 | 8 | 13 | +1 | 47 |
| 10 | Montreal Impact | 34 | 12 | 10 | 12 | +2 | 46 |
| 11 | Inter Miami | 34 | 12 | 5 | 17 | -17 | 41 |
| 12 | Chicago Fire | 34 | 9 | 7 | 18 | -18 | 34 |
| 13 | Toronto FC | 34 | 6 | 10 | 18 | -27 | 28 |
| 14 | FC Cincinnati | 34 | 4 | 8 | 22 | -37 | 20 |
| # | Team | P | Diff | Pts |
|---|---|---|---|---|
| 1 | New England Revolution | 34 | +24 | 73 |
| 2 | Philadelphia Union | 34 | +13 | 54 |
| 3 | Nashville SC | 34 | +22 | 54 |
| 4 | New York City FC | 34 | +20 | 51 |
| 5 | Atlanta United FC | 34 | +8 | 51 |
| 6 | Orlando City SC | 34 | +2 | 51 |
| 7 | New York Red Bulls | 34 | +6 | 48 |
| 8 | DC United | 34 | +2 | 47 |
| 9 | Columbus Crew | 34 | +1 | 47 |
| 10 | Montreal Impact | 34 | +2 | 46 |
| 11 | Inter Miami | 34 | -17 | 41 |
| 12 | Chicago Fire | 34 | -18 | 34 |
| 13 | Toronto FC | 34 | -27 | 28 |
| 14 | FC Cincinnati | 34 | -37 | 20 |