| # | Team | P | W | D | L | GF | GA | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Plaza Colonia | 15 | 11 | 3 | 1 | 20 | 7 | +13 | 36 | WWDWW |
| 2 | Club Nacional | 15 | 9 | 2 | 4 | 23 | 14 | +9 | 29 | LWLWW |
| 3 | Penarol | 15 | 7 | 7 | 1 | 22 | 10 | +12 | 28 | DWWWD |
| 4 | Liverpool Montevideo | 15 | 8 | 3 | 4 | 38 | 20 | +18 | 27 | WLDWD |
| 5 | CA River Plate | 15 | 7 | 5 | 3 | 27 | 20 | +7 | 26 | WDDLD |
| 6 | Atletico Torque | 15 | 8 | 1 | 6 | 26 | 19 | +7 | 25 | WWDLL |
| 7 | Fenix | 15 | 6 | 3 | 6 | 20 | 22 | -2 | 21 | WWDLD |
| 8 | Cerro Largo | 15 | 6 | 2 | 7 | 20 | 22 | -2 | 20 | WLLWW |
| 9 | Cerrito | 15 | 5 | 4 | 6 | 14 | 15 | -1 | 19 | LDWDW |
| 10 | SUD America | 15 | 5 | 3 | 7 | 15 | 22 | -7 | 18 | DWWLD |
| 11 | Wanderers | 15 | 5 | 2 | 8 | 12 | 16 | -4 | 17 | LLLWL |
| 12 | Rentistas | 15 | 4 | 4 | 7 | 12 | 21 | -9 | 16 | LLDLD |
| 13 | Boston River | 15 | 3 | 5 | 7 | 14 | 19 | -5 | 14 | WLDWL |
| 14 | Deportivo Maldonado | 15 | 3 | 5 | 7 | 11 | 22 | -11 | 14 | LDDLL |
| 15 | Progreso | 15 | 2 | 5 | 8 | 13 | 26 | -13 | 11 | LLDLW |
| 16 | Villa Espanola | 15 | 1 | 6 | 8 | 14 | 26 | -12 | 9 | LDDDL |
Player stats
Primera División match stats only.
SUD America finished 10th in the Primera División in 2021 with 18 points (5W 3D 7L). They scored 15 and conceded 22, a goal difference of -7. Jorge Ramírez top-scored with 4 goals. The final table, every result and the season's team statistics are below.
