| # | Team | P | W | D | L | GF | GA | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Manchester City | 38 | 27 | 5 | 6 | 83 | 32 | +51 | 86 | WLWLW |
| 2 | Manchester United | 38 | 21 | 11 | 6 | 73 | 44 | +29 | 74 | WDLLW |
| 3 | Liverpool | 38 | 20 | 9 | 9 | 68 | 42 | +26 | 69 | WWWWW |
| 4 | Chelsea | 38 | 19 | 10 | 9 | 58 | 36 | +22 | 67 | LWLWW |
| 5 | Leicester | 38 | 20 | 6 | 12 | 68 | 50 | +18 | 66 | LLWLD |
| 6 | West Ham | 38 | 19 | 8 | 11 | 62 | 47 | +15 | 65 | WWDLW |
| 7 | Tottenham | 38 | 18 | 8 | 12 | 68 | 45 | +23 | 62 | WLWLW |
| 8 | Arsenal | 38 | 18 | 7 | 13 | 55 | 39 | +16 | 61 | WWWWW |
| 9 | Leeds | 38 | 18 | 5 | 15 | 62 | 54 | +8 | 59 | WWWWL |
| 10 | Everton | 38 | 17 | 8 | 13 | 47 | 48 | -1 | 59 | LWLDW |
| 11 | Aston Villa | 38 | 16 | 7 | 15 | 55 | 46 | +9 | 55 | WWLDL |
| 12 | Newcastle | 38 | 12 | 9 | 17 | 46 | 62 | -16 | 45 | WWLWL |
| 13 | Wolves | 38 | 12 | 9 | 17 | 36 | 52 | -16 | 45 | LLLWD |
| 14 | Crystal Palace | 38 | 12 | 8 | 18 | 41 | 66 | -25 | 44 | LLWLW |
| 15 | Southampton | 38 | 12 | 7 | 19 | 47 | 68 | -21 | 43 | LLWWL |
| 16 | Brighton | 38 | 9 | 14 | 15 | 40 | 46 | -6 | 41 | LWDLW |
| 17 | Burnley | 38 | 10 | 9 | 19 | 33 | 55 | -22 | 39 | LLLWL |
| 18 | Fulham | 38 | 5 | 13 | 20 | 27 | 53 | -26 | 28 | LDLLL |
| 19 | West Brom | 38 | 5 | 11 | 22 | 35 | 76 | -41 | 26 | LLLLD |
| 20 | Sheffield Utd | 38 | 7 | 2 | 29 | 20 | 63 | -43 | 23 | WLWLL |
Player stats
Premier League match stats only.
Premier League match stats only.
Southampton finished 15th in the Premier League in 2020/21 with 43 points (12W 7D 19L). They scored 47 and conceded 68, a goal difference of -21. The final table, every result and the season's team statistics are below.