| # | Team | P | W | D | L | GF | GA | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Shamrock Rovers | 36 | 24 | 6 | 6 | 59 | 28 | +31 | 78 | WLWWW |
| 2 | St Patrick's Athl. | 36 | 18 | 8 | 10 | 56 | 42 | +14 | 62 | DDLDW |
| 3 | Sligo Rovers | 36 | 16 | 9 | 11 | 43 | 32 | +11 | 57 | DLWWW |
| 4 | Derry City | 36 | 14 | 12 | 10 | 49 | 42 | +7 | 54 | WWDDD |
| 5 | Bohemians | 36 | 14 | 10 | 12 | 60 | 46 | +14 | 52 | DWWDD |
| 6 | Dundalk | 36 | 13 | 9 | 14 | 44 | 46 | -2 | 48 | LWWWL |
| 7 | Drogheda United | 36 | 12 | 8 | 16 | 45 | 43 | +2 | 44 | LLLDL |
| 8 | Finn Harps | 36 | 11 | 11 | 14 | 44 | 52 | -8 | 44 | WDDDL |
| 9 | Waterford | 36 | 12 | 6 | 18 | 36 | 56 | -20 | 42 | DDLDL |
| 10 | Longford Town | 36 | 2 | 9 | 25 | 22 | 71 | -49 | 15 | LDLLL |
Player stats
LOI Premier Division match stats only.
Sligo Rovers finished 3rd in the LOI Premier Division in 2021 with 57 points (16W 9D 11L). They scored 43 and conceded 32, a goal difference of +11. J. Kenny top-scored with 11 goals. The final table, every result and the season's team statistics are below.
