| # | Team | P | W | D | L | GF | GA | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Hamrun Spartans | 23 | 17 | 5 | 1 | 56 | 20 | +36 | 56 | WWWWW |
| 2 | Hibernians | 23 | 16 | 3 | 4 | 53 | 20 | +33 | 51 | LWWWW |
| 3 | Gzira United | 23 | 14 | 4 | 5 | 49 | 21 | +28 | 46 | LLWWW |
| 4 | Birkirkara | 23 | 13 | 5 | 5 | 45 | 25 | +20 | 44 | WWDWL |
| 5 | Sliema Wanderers | 23 | 12 | 4 | 7 | 39 | 31 | +8 | 40 | WLDDW |
| 6 | Mosta | 23 | 10 | 6 | 7 | 41 | 36 | +5 | 36 | WWDWL |
| 7 | Valletta FC | 23 | 9 | 6 | 8 | 27 | 35 | -8 | 33 | LWWLW |
| 8 | Santa Lucía | 23 | 7 | 8 | 8 | 38 | 35 | +3 | 29 | LLLWD |
| 9 | Sirens | 23 | 7 | 7 | 9 | 27 | 35 | -8 | 28 | DDDLL |
| 10 | Balzan FC | 23 | 6 | 9 | 8 | 31 | 29 | +2 | 27 | WDWLD |
| 11 | Gudja United | 23 | 8 | 3 | 12 | 29 | 35 | -6 | 27 | WLLLD |
| 12 | Floriana | 23 | 7 | 6 | 10 | 26 | 34 | -8 | 27 | DLWWD |
| 13 | Zejtun Corinthians | 23 | 6 | 6 | 11 | 28 | 40 | -12 | 24 | LDLLL |
| 14 | Tarxien Rainbows | 23 | 6 | 3 | 14 | 25 | 48 | -23 | 21 | LWWLW |
| 15 | Lija Athletic | 23 | 5 | 5 | 13 | 25 | 46 | -21 | 20 | WDLWL |
| 16 | Senglea Athletic | 23 | 0 | 2 | 21 | 13 | 62 | -49 | 2 | LLLLL |
Player stats
Maltese Premier League match stats only.
Senglea Athletic were relegated in the Maltese Premier League in 2020/21, finishing 16th with 2 points (0W 2D 21L). They scored 13 and conceded 62, a goal difference of -49. Dibola Diwoto Júnior top-scored with 5 goals. The final table, every result and the season's team statistics are below.
