| # | Team | P | W | D | L | GF | GA | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Wigan | 46 | 27 | 11 | 8 | 82 | 44 | +38 | 92 | WLDDL |
| 2 | Rotherham | 46 | 27 | 9 | 10 | 70 | 33 | +37 | 90 | WDWLW |
| 3 | Milton Keynes Dons | 46 | 26 | 11 | 9 | 78 | 44 | +34 | 89 | WWLLD |
| 4 | Sheffield Wednesday | 46 | 24 | 13 | 9 | 78 | 50 | +28 | 85 | WWLWW |
| 5 | Sunderland | 46 | 24 | 12 | 10 | 79 | 53 | +26 | 84 | WDWDW |
| 6 | Wycombe | 46 | 23 | 14 | 9 | 75 | 51 | +24 | 83 | WWDWD |
| 7 | Plymouth | 46 | 23 | 11 | 12 | 68 | 48 | +20 | 80 | LDDLD |
| 8 | Oxford United | 46 | 22 | 10 | 14 | 82 | 59 | +23 | 76 | DLWWL |
| 9 | Bolton | 46 | 21 | 10 | 15 | 74 | 57 | +17 | 73 | WWWWD |
| 10 | Portsmouth | 46 | 20 | 13 | 13 | 68 | 51 | +17 | 73 | LWWDW |
| 11 | Ipswich | 46 | 18 | 16 | 12 | 67 | 46 | +21 | 70 | WDDLD |
| 12 | Accrington ST | 46 | 17 | 10 | 19 | 61 | 80 | -19 | 61 | WWLDW |
| 13 | Charlton | 46 | 17 | 8 | 21 | 55 | 59 | -4 | 59 | LWWLW |
| 14 | Cambridge United | 46 | 15 | 13 | 18 | 56 | 74 | -18 | 58 | DLLWW |
| 15 | Cheltenham | 46 | 13 | 17 | 16 | 66 | 80 | -14 | 56 | DLLDW |
| 16 | Burton Albion | 46 | 14 | 11 | 21 | 51 | 67 | -16 | 53 | LLWDD |
| 17 | Lincoln | 46 | 14 | 10 | 22 | 55 | 63 | -8 | 52 | WLWLL |
| 18 | Shrewsbury | 46 | 12 | 14 | 20 | 47 | 51 | -4 | 50 | LLDLD |
| 19 | Morecambe | 46 | 10 | 12 | 24 | 57 | 88 | -31 | 42 | LLDWL |
| 20 | Fleetwood Town | 46 | 8 | 16 | 22 | 62 | 82 | -20 | 40 | LLDDL |
| 21 | Gillingham | 46 | 8 | 16 | 22 | 35 | 69 | -34 | 40 | LLDDD |
| 22 | Doncaster | 46 | 10 | 8 | 28 | 37 | 82 | -45 | 38 | DWDLW |
| 23 | AFC Wimbledon | 46 | 6 | 19 | 21 | 49 | 75 | -26 | 37 | LDDLD |
| 24 | Crewe | 46 | 7 | 8 | 31 | 37 | 83 | -46 | 29 | LDLWL |
Player stats
League One match stats only.
Rotherham finished 2nd in the League One in 2021/22 with 90 points (27W 9D 10L). They scored 70 and conceded 33, a goal difference of +37. Michael Smith top-scored with 19 goals and Benjamin Wiles and Daniel Barlaser led the assists with 7 each. The final table, every result and the season's team statistics are below.
