| # | Team | P | W | D | L | GF | GA | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | FC Schalke 04 | 34 | 20 | 5 | 9 | 72 | 44 | +28 | 65 | WWWLW |
| 2 | Werder Bremen | 34 | 18 | 9 | 7 | 65 | 43 | +22 | 63 | WWLWD |
| 3 | Hamburger SV | 34 | 16 | 12 | 6 | 67 | 35 | +32 | 60 | WWWWW |
| 4 | SV Darmstadt 98 | 34 | 18 | 6 | 10 | 71 | 46 | +25 | 60 | WLWWL |
| 5 | FC St. Pauli | 34 | 16 | 9 | 9 | 61 | 46 | +15 | 57 | WLDLD |
| 6 | 1. FC Heidenheim | 34 | 15 | 7 | 12 | 43 | 45 | -2 | 52 | WWLDL |
| 7 | SC Paderborn 07 | 34 | 13 | 12 | 9 | 56 | 44 | +12 | 51 | LWDWW |
| 8 | 1. FC Nürnberg | 34 | 14 | 9 | 11 | 49 | 49 | 0 | 51 | LLDLD |
| 9 | Holstein Kiel | 34 | 12 | 9 | 13 | 46 | 54 | -8 | 45 | LWWDD |
| 10 | Fortuna Düsseldorf | 34 | 11 | 11 | 12 | 45 | 42 | +3 | 44 | LWWDD |
| 11 | Hannover 96 | 34 | 11 | 9 | 14 | 35 | 49 | -14 | 42 | WLWLD |
| 12 | Karlsruher SC | 34 | 9 | 14 | 11 | 54 | 55 | -1 | 41 | LDLDL |
| 13 | Hansa Rostock | 34 | 10 | 11 | 13 | 41 | 52 | -11 | 41 | LDDDD |
| 14 | SV Sandhausen | 34 | 10 | 11 | 13 | 42 | 54 | -12 | 41 | WLLWD |
| 15 | SSV Jahn Regensburg | 34 | 10 | 10 | 14 | 50 | 51 | -1 | 40 | LLDLD |
| 16 | Dynamo Dresden | 34 | 7 | 11 | 16 | 33 | 46 | -13 | 32 | LDDDD |
| 17 | Erzgebirge Aue | 34 | 6 | 8 | 20 | 32 | 72 | -40 | 26 | WLLDW |
| 18 | FC Ingolstadt 04 | 34 | 4 | 9 | 21 | 30 | 65 | -35 | 21 | LDLDL |
| 19 | 1. FC Kaiserslautern | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Player stats
2. Bundesliga match stats only.
2. Bundesliga match stats only.
Karlsruher SC finished 12th in the 2. Bundesliga in 2021/22 with 41 points (9W 14D 11L). They scored 54 and conceded 55, a goal difference of -1. The final table, every result and the season's team statistics are below.